The Anti-Oct4 Mouse mAb Antibody from MyBioSource.com is a Mouse Monoclonal antibody to pou5f1. This antibody recognizes Human antigen. The Anti-Oct4 Mouse mAb Antibody has been validated for the following applications: Flow Cytometry, Immunocytochemistry, and Western Blot.
Description
Entrez Summary: This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t (6; 22) (p21; q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues